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Regenerative medicine therapy for single ventricle congenital heart disease

by Sudhish Sharma | Apr 2, 2018 | Journals, Uncategorized

Abstract One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the...

The current status and future of cardiac stem/progenitor cell therapy for congenital heart defects from diabetic pregnancy

by Sudhish Sharma | Jan 10, 2018 | Journals, Uncategorized

Abstract Pregestational maternal diabetes induces congenital heart defects (CHDs). Cardiac dysfunction after palliative surgical procedures contributes to the high mortality of CHD patients. Autologous or allogeneic stem cell therapies are effective for improving...

A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells

by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized

Abstract Rationale—Cardiac progenitor cells are an attractive cell type for tissue regeneration but their mechanism for myocardial remodeling is still unclear. Objective—This investigation determines how chronological age influences the phenotypic characteristics and...

Young Hearts Run Free: Therapeutic Potential of Neonatal Human Cardiac Progenitor Cells Secretome

by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized

Abstract Stem cell hypothesis of aging postulates that youthful stem cells have better intrinsic ability to repair/regenerate after an injury. Consistent with this hypothesis, current report by Sharma et al observed nCPCs transplantation post-MI was associated with...

Stem Cell Therapy For Congenital Heart Disease: Toward Translation

by Sudhish Sharma | Aug 10, 2015 | Journals, Uncategorized

Abstract Stem cell therapy has the optimistic goal of regenerating the myocardium as defined by regrowth of lost or destroyed myocardium. As applied to patients with heart failure, many confuse or limit the regenerative definition to just improving myocardial function...

Pediatric End-Stage Failing Hearts Demonstrate Increased Cardiac Stem Cells

by Sudhish Sharma | Aug 2, 2015 | Journals, Uncategorized

Abstract Background—We sought to determine the location, expression, and characterization of cardiac stem cells (CSCs) in children with end-stage heart failure (ESHF). We hypothesized ESHF myocardium would contain an increased number of CSCs relative to age-matched...
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