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Stem Cell Therapy For Congenital Heart Disease: Toward Translation

by Sudhish Sharma | Aug 10, 2015 | Journals, Uncategorized

Abstract Stem cell therapy has the optimistic goal of regenerating the myocardium as defined by regrowth of lost or destroyed myocardium. As applied to patients with heart failure, many confuse or limit the regenerative definition to just improving myocardial function...

Pediatric End-Stage Failing Hearts Demonstrate Increased Cardiac Stem Cells

by Sudhish Sharma | Aug 2, 2015 | Journals, Uncategorized

Abstract Background—We sought to determine the location, expression, and characterization of cardiac stem cells (CSCs) in children with end-stage heart failure (ESHF). We hypothesized ESHF myocardium would contain an increased number of CSCs relative to age-matched...

Cardiosphere Derived Cells from Pediatric End-Stage Heart Failure Patients Have Enhanced Functional Activity due to the Heat Shock Response Regulating the Secretome

by Sudhish Sharma | Apr 2, 2015 | Journals, Uncategorized

Abstract We have demonstrated that human neonatal cardiosphere derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs....

Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death

by Sudhish Sharma | Jun 5, 2014 | Journals, Uncategorized

Abstract Protein homeostatic regulators have been shown toameliorate single, loss-of-function protein diseases but not totreat broader animal disease models that may involve celldeath. Diseases often trigger protein homeostatic instabilitythat disrupts the delicate...

A Strong Regenerative Ability of Cardiac Stem Cells Derived From Neonatal Hearts

by Sudhish Sharma | Sep 11, 2012 | Journals, Uncategorized

Abstract Background—Human stem cells (CSCs) promote myocardial regeneration in adult ischemic myocardium. The regenerative capacity of CSCs in the very young patients with non-ischemic congenital heart defects has not been explored. We hypothesized that isolated...

Characterization and Functionality of Cardiac Progenitor Cells in Congenital Heart Patients

by Sudhish Sharma | Feb 1, 2011 | Journals, Uncategorized

Abstract Background—Human cardiac progenitor cells (hCPCs) may promote myocardial regenerationin adult ischemic myocardium. The regenerative capacity of hCPCs in young patients withnonischemic congenital heart defects for potential use in congenital heart defect...
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