by Sudhish Sharma | May 22, 2019 | Journals, Uncategorized
Abstract The stem cell field is hindered by its inability to noninvasively monitor transplanted cells within the target organ in a repeatable, time-sensitive, and condition-specific manner. We hypothesized that quantifying and characterizing transplanted cell–derived...
by Sudhish Sharma | Jul 6, 2018 | Journals, Uncategorized
Abstract Hypoplastic left heart syndrome is a type of congenital heart disease characterized by underdevelopment of the left ventricle, outflow tract, and aorta. The condition is fatal if aggressive palliative operations are not undertaken, but even after the complete...
by Sudhish Sharma | Apr 2, 2018 | Journals, Uncategorized
Abstract One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the...
by Sudhish Sharma | Jan 10, 2018 | Journals, Uncategorized
Abstract Pregestational maternal diabetes induces congenital heart defects (CHDs). Cardiac dysfunction after palliative surgical procedures contributes to the high mortality of CHD patients. Autologous or allogeneic stem cell therapies are effective for improving...
by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized
Abstract Rationale—Cardiac progenitor cells are an attractive cell type for tissue regeneration but their mechanism for myocardial remodeling is still unclear. Objective—This investigation determines how chronological age influences the phenotypic characteristics and...
by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized
Abstract Stem cell hypothesis of aging postulates that youthful stem cells have better intrinsic ability to repair/regenerate after an injury. Consistent with this hypothesis, current report by Sharma et al observed nCPCs transplantation post-MI was associated with...
by Sudhish Sharma | Aug 10, 2015 | Journals, Uncategorized
Abstract Stem cell therapy has the optimistic goal of regenerating the myocardium as defined by regrowth of lost or destroyed myocardium. As applied to patients with heart failure, many confuse or limit the regenerative definition to just improving myocardial function...
by Sudhish Sharma | Aug 2, 2015 | Journals, Uncategorized
Abstract Background—We sought to determine the location, expression, and characterization of cardiac stem cells (CSCs) in children with end-stage heart failure (ESHF). We hypothesized ESHF myocardium would contain an increased number of CSCs relative to age-matched...
by Sudhish Sharma | Apr 2, 2015 | Journals, Uncategorized
Abstract We have demonstrated that human neonatal cardiosphere derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs....
by Sudhish Sharma | Jun 5, 2014 | Journals, Uncategorized
Abstract Protein homeostatic regulators have been shown toameliorate single, loss-of-function protein diseases but not totreat broader animal disease models that may involve celldeath. Diseases often trigger protein homeostatic instabilitythat disrupts the delicate...
