by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized
Abstract Stem cell hypothesis of aging postulates that youthful stem cells have better intrinsic ability to repair/regenerate after an injury. Consistent with this hypothesis, current report by Sharma et al observed nCPCs transplantation post-MI was associated with...
by Sudhish Sharma | Aug 10, 2015 | Journals, Uncategorized
Abstract Stem cell therapy has the optimistic goal of regenerating the myocardium as defined by regrowth of lost or destroyed myocardium. As applied to patients with heart failure, many confuse or limit the regenerative definition to just improving myocardial function...
by Sudhish Sharma | Aug 2, 2015 | Journals, Uncategorized
Abstract Background—We sought to determine the location, expression, and characterization of cardiac stem cells (CSCs) in children with end-stage heart failure (ESHF). We hypothesized ESHF myocardium would contain an increased number of CSCs relative to age-matched...
by Sudhish Sharma | Apr 2, 2015 | Journals, Uncategorized
Abstract We have demonstrated that human neonatal cardiosphere derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs....
by Sudhish Sharma | Jun 5, 2014 | Journals, Uncategorized
Abstract Protein homeostatic regulators have been shown toameliorate single, loss-of-function protein diseases but not totreat broader animal disease models that may involve celldeath. Diseases often trigger protein homeostatic instabilitythat disrupts the delicate...
by Sudhish Sharma | Sep 11, 2012 | Journals, Uncategorized
Abstract Background—Human stem cells (CSCs) promote myocardial regeneration in adult ischemic myocardium. The regenerative capacity of CSCs in the very young patients with non-ischemic congenital heart defects has not been explored. We hypothesized that isolated...
