Innovative Therapies Rooted in Science

Pioneering nCPC-Based Therapies

The Secretome: Nature’s Healing Blueprint

Revolutionizing Regenerative Medicine

Our scientific team has developed a proprietary platform to isolate and mass-produce nCPCs, which secrete a unique and highly potent secretome. We have identified several key factors within the nCPC secretome that have shown promising therapeutic effects in preclinical studies.

Pharmacology as Complex as the Diseases We Treat:

Reduce Inflammation

nCPC reduce inflammation at both cellular and molecular levels

  • Conversion of activated CD4+ T-cells to anti-inflammatory Treg cells
  • Re-polarization of macrophage from M1 (pro-inflammatory) to M2 (anti-inflammatory, reparative) phenotype
  • Systemic and organ-specific reductions in pro-inflammatory cytokines including TNF-a, IL-6, IFN-g
  • Increases in anti-inflammatory cytokines including IL-10

Regenerate Tissue

Mechanism: nCPC secretomes promote the growth and repair of damaged tissues by providing essential growth factors and stimulating cell proliferation.

Evidence: Studies in juvenile mice with cardiomyopathy show improved cardiac structure and function after treatment with nCPCs, including reduced fibrosis and increased wall thickness. nCPC secretomes have shown promise in preclinical models of muscular dystrophy and neurodegenerative diseases, promoting tissue repair and functional recovery.

Significance: Regenerating damaged tissues is critical for restoring organ function and improving patient outcomes in a wide range of diseases.

Promote Angiogenesis

nCPC stimulate the formation of new blood vessels, crucial for tissue regeneration and repair.

Evidence: Animal models of heart failure show increased blood vessel formation and improved blood supply to damaged tissues after treatment with nCPC secretomes. In vitro assays using human cells demonstrate the nCPC secretome’s ability to induce angiogenesis.

Significance: Promoting angiogenesis is vital for treating ischemic diseases, improving wound healing, and supporting tissue regeneration in various conditions.

Modulate the Immune System

Mechanism: nCPC secretomes can modulate the activity of immune cells, promoting a balanced immune response and reducing harmful inflammation.

Evidence: Research demonstrates the nCPC secretome’s ability to enhance the activity of regulatory T cells (Tregs), which play a crucial role in immune system regulation. In vivo studies show that nCPC secretomes can dampen autoimmune responses and reduce inflammation in models of type 1 diabetes.

Significance: Modulating the immune system is essential for treating autoimmune diseases, preventing transplant rejection, and promoting tissue regeneration. Sources and related content

Pioneering Research and Development

At Secretome Therapeutics, our research and development efforts are the cornerstone of our mission to revolutionize cardiovascular and inflammatory disease treatment. We are committed to advancing the science of neonatal cardiac progenitor cells and their secretome, which includes bioactive molecules like cytokines and exosomes. Our partnerships with leading academic and clinical institutions enable us to push the boundaries of regenerative medicine, ensuring that our therapies are not only innovative but also effective in improving patient outcomes. Through rigorous research, we aim to deliver groundbreaking solutions that address unmet medical needs and transform healthcare.