Our Science

At Secretome Therapeutics, our science is rooted in decades of pioneering research into neonatal cardiac progenitor cells (nCPCs) and their secretome. These bioactive molecules, released by nCPCs, include cytokines, growth factors, and exosomes. Collectively, they promote tissue repair, reduce inflammation, and enhance immune modulation.

Key findings from our research include:

  • Enhanced Efficacy: Neonatal CPCs outperform adult-derived cells in regenerative ability due to their superior secretome composition.

  • Immunomodulation: Our studies highlight the role of nCPCs in balancing inflammatory responses and promoting M2 macrophage polarization, leading to long-lasting tissue repair.

  • Cell-Free Therapies: Evidence supports that nCPC-derived exosomes alone can deliver therapeutic benefits, underscoring a shift towards cell-free regenerative medicine.

Mechanisms of Action

The Secretome

The secretome is a complex mixture of molecules responsible for the therapeutic effects observed in preclinical studies. These molecules act via:

  • Immune Remodeling: Promoting anti-inflammatory macrophages (M2 type) and enhancing regulatory T-cell activity to mitigate tissue damage.

  • Tissue Repair: Stimulating angiogenesis and reducing fibrosis in damaged myocardium and other tissues.

  • Precision-Driven Recovery: Delivering a tailored response to specific injury sites facilitated by the exosome’s miRNA cargo.

Advanced Therapeutic Insights

Heart Failure with Preserved Ejection Fraction (HFpEF): Research demonstrates robust myocardial recovery with reduced fibrosis and enhanced cardiac function.

Chronic Inflammatory Conditions: Preclinical data suggest that the secretome modulates inflammation effectively in conditions like Crohn’s disease and other systemic inflammatory disorders.

Commitment to Innovation

At Secretome Therapeutics, we are not merely developing treatments but defining a new paradigm for regenerative medicine. By leveraging nCPC-derived technologies, we aim to create accessible, scalable, and highly effective therapeutic solutions for previously untreatable conditions.

Please contact us directly with any questions,
comments, or inquiries you may have.

 

Secretome Therapeutics

323 W. Camden Street, Suite 600
Baltimore, MD 21201

400 N. Aberdeen Street, Suite  900
Chicago, IL 60642

7250 Dallas Parkway, Suite 400
Plano, TX 75024

3060 Pegasus Park Drive, Building 6
Dallas, TX 75247