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A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells

by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized

Abstract Rationale—Cardiac progenitor cells are an attractive cell type for tissue regeneration but their mechanism for myocardial remodeling is still unclear. Objective—This investigation determines how chronological age influences the phenotypic characteristics and...

Young Hearts Run Free: Therapeutic Potential of Neonatal Human Cardiac Progenitor Cells Secretome

by Sudhish Sharma | Mar 3, 2017 | Journals, Uncategorized

Abstract Stem cell hypothesis of aging postulates that youthful stem cells have better intrinsic ability to repair/regenerate after an injury. Consistent with this hypothesis, current report by Sharma et al observed nCPCs transplantation post-MI was associated with...

Stem Cell Therapy For Congenital Heart Disease: Toward Translation

by Sudhish Sharma | Aug 10, 2015 | Journals, Uncategorized

Abstract Stem cell therapy has the optimistic goal of regenerating the myocardium as defined by regrowth of lost or destroyed myocardium. As applied to patients with heart failure, many confuse or limit the regenerative definition to just improving myocardial function...

Pediatric End-Stage Failing Hearts Demonstrate Increased Cardiac Stem Cells

by Sudhish Sharma | Aug 2, 2015 | Journals, Uncategorized

Abstract Background—We sought to determine the location, expression, and characterization of cardiac stem cells (CSCs) in children with end-stage heart failure (ESHF). We hypothesized ESHF myocardium would contain an increased number of CSCs relative to age-matched...

Cardiosphere Derived Cells from Pediatric End-Stage Heart Failure Patients Have Enhanced Functional Activity due to the Heat Shock Response Regulating the Secretome

by Sudhish Sharma | Apr 2, 2015 | Journals, Uncategorized

Abstract We have demonstrated that human neonatal cardiosphere derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs....
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Recent Posts

  • NeoProgen receives approval from U.S. FDA for a Phase I Study of The Safety And Early Efficacy of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) In Chronic Ischemic Heart Failure
  • NeoProgen, Inc. Receives First Granted Patent for Method to Treat Cardiac Conditions using Neonatal Heart-derived Medicinal Signaling Cells (nMSCs) and/or their Secretomes/Exosomes from the US Patent Office
  • Secretome Therapeutics Presents Scientific Poster on the Essential Role of Complete Secretome in Regenerative Cell Therapy at ISSCR 2023 Annual Meeting
  • Secretome Therapeutics Announces Appointment of Angela Shen, M.D., M.B.A., to Board of Directors
  • Comparative efficacy and mechanism of action of cardiac progenitor cells after cardiac injury
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